Preheat your oven to 375°F (190°C). Line a baking dish with aluminum foil for easier cleanup.

In a small bowl, combine garlic powder, onion powder, paprika, salt, black pepper, and cayenne (if using).

Pat the chicken breasts dry with paper towels. This helps the seasonings stick and promotes crispy skin.

Rub the chicken breasts with olive oil, then sprinkle generously with the spice mixture, making sure to season both sides.

Place the seasoned chicken breasts skin-side up in the prepared baking dish, allowing some space between pieces.

Bake in the preheated oven for about 25 minutes.

Remove the chicken from the oven and generously brush each piece with barbecue sauce, making sure to cover all exposed surfaces.

Return the chicken to the oven and continue baking for another 15-20 minutes, or until the internal temperature reaches 165°F (74°C) and the sauce has caramelized slightly.

For extra caramelization, you can turn on the broiler for the final 2-3 minutes. Watch carefully to prevent burning!

Remove from oven and let the chicken rest for 5 minutes before serving to allow the juices to redistribute.